› 1rk4

X-ray diffraction
1.79Å resolution

Crystal Structure of a Soluble Dimeric Form of Oxidised CLIC1

Released:
DOI: 10.2210/pdb1rk4/pdb
PDB entry 1rk4 coloured by chain, front view.
PDB entry 1rk4 coloured by chain, side view.
PDB entry 1rk4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition.
Littler DR, Harrop SJ, Fairlie WD, Brown LJ, Pankhurst GJ, Pankhurst S, DeMaere MZ, Campbell TJ, Bauskin AR, Tonini R, Mazzanti M, Breit SN, Curmi PM
J Biol Chem 279 9298-305 (2004)
PMID: 14613939

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126231 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chloride intracellular channel protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 243 amino acids
Theoretical weight: 27.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00299 (Residues: 1-241; Coverage: 100%)
Gene names: CLIC1, G6, NCC27
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS
Spacegroup: P212121
Unit cell:
a: 59.861Å b: 69.189Å c: 107.506Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.213
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Glutathione transferases.
Hayes et al. (2005)
24 more

12 mentions without citation

Proteins that switch folds.
Bryan et al. (2010)
11 more