› 1rn7

X-ray diffraction
2.5Å resolution

Structure of human cystatin D

Released:
DOI: 10.2210/pdb1rn7/pdb
PDB entry 1rn7 coloured by chain, front view.
PDB entry 1rn7 coloured by chain, side view.
PDB entry 1rn7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile.
Alvarez-Fernandez M, Liang YH, Abrahamson M, Su XD
J Biol Chem 280 18221-8 (2005)
PMID: 15728581

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151204 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystatin-D Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 13.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P28325 (Residues: 21-142; Coverage: 100%)
Gene name: CST5
Sequence domains: Cystatin domain
Structure domains: Nuclear Transport Factor 2; Chain: A,

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21212
Unit cell:
a: 34.9Å b: 84.37Å c: 47.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.191 0.229
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Variations in MHC Class II Antigen Processing and Presentation in Health and Disease.
Unanue et al. (2016)
4 more

8 mentions without citation

The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors.
Pišlar et al. (2020)
7 more