› 1rp1

X-ray diffraction
2.1Å resolution

DOG PANCREATIC LIPASE RELATED PROTEIN 1

Released:
DOI: 10.2210/pdb1rp1/pdb
PDB entry 1rp1 coloured by chain, front view.
PDB entry 1rp1 coloured by chain, side view.
PDB entry 1rp1 coloured by chain, top view.
Source organism: Canis lupus familiaris
Primary publication:
Reactivation of the totally inactive pancreatic lipase RP1 by structure-predicted point mutations.
Roussel A, de Caro J, Bezzine S, Gastinel L, de Caro A, Carrière F, Leydier S, Verger R, Cambillau C
Proteins 32 523-31 (1998)
PMID: 9726421

Function and Biology Details

Reaction catalysed: 
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139259 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inactive pancreatic lipase-related protein 1 Chain: A
Molecule details ›
Chain: A
Length: 450 amino acids
Theoretical weight: 49.68 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: P06857 (Residues: 18-467; Coverage: 100%)
Gene names: PLRP1, PNLIPRP1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 1 x NAG
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE BEAMLINE DW32
Spacegroup: C2221
Unit cell:
a: 54.026Å b: 150.748Å c: 132.006Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.195 0.256

Quick links

Citations

7 review citations

Human pancreatic digestive enzymes.
Whitcomb et al. (2007)
6 more

5 mentions without citation

The TetR family of transcriptional repressors.
Ramos et al. (2005)
4 more