› 1rw5

Solution NMR

Solution structure of human prolactin

Released:
DOI: 10.2210/pdb1rw5/pdb
PDB entry 1rw5 coloured by chain, ensemble of 20 models, front view.
PDB entry 1rw5 coloured by chain, ensemble of 20 models, side view.
PDB entry 1rw5 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of human prolactin.
Teilum K, Hoch JC, Goffin V, Kinet S, Martial JA, Kragelund BB
J Mol Biol 351 810-23 (2005)
PMID: 16045928

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134122 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prolactin Chain: A
Molecule details ›
Chain: A
Length: 199 amino acids
Theoretical weight: 22.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01236 (Residues: 29-227; Coverage: 100%)
Gene name: PRL
Sequence domains: Somatotropin hormone family
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

8 review citations

Drug Insight: prolactin-receptor antagonists, a novel approach to treatment of unresolved systemic and local hyperprolactinemia?
Goffin et al. (2006)
7 more

22 mentions without citation

Molecular mechanisms of prolactin and its receptor.
Brooks CL. (2012)
21 more