› 1s45

X-ray diffraction
2.2Å resolution

Crystal structure analysis of the DNA quadruplex d(TGGGGT) S1

Released:
DOI: 10.2210/pdb1s45/pdb
PDB entry 1s45 coloured by chain, front view.
PDB entry 1s45 coloured by chain, side view.
PDB entry 1s45 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
A thymine tetrad in d(TGGGGT) quadruplexes stabilized with Tl+/Na+ ions.
Cáceres C, Wright G, Gouyette C, Parkinson G, Subirana JA
Nucleic Acids Res 32 1097-102 (2004)
PMID: 14960719

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114571 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*TP*GP*GP*GP*GP*T)-3' Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 6 nucleotides
Theoretical weight: 1.88 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand TL 6 x TL
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P1
Unit cell:
a: 28.259Å b: 35.41Å c: 32.057Å
α: 83.73° β: 61.78° γ: 76.68°
R-values:
R R work R free
0.195 0.173 0.239
Expression system: Not provided

Quick links

Citations

9 review citations

The application of DNA and RNA G-quadruplexes to therapeutic medicines.
Collie et al. (2011)
8 more

11 mentions without citation

G-quadruplex virtual drug screening: A review.
Monsen et al. (2018)
10 more