› 1s4q

X-ray diffraction
2.16Å resolution

Crystal Structure of Guanylate Kinase from Mycobacterium tuberculosis (Rv1389)

Released:
DOI: 10.2210/pdb1s4q/pdb
PDB entry 1s4q coloured by chain, front view.
PDB entry 1s4q coloured by chain, side view.
PDB entry 1s4q coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Entry authors: Chan S, Sawaya MR, Perry LJ, Eisenberg D, TB Structural Genomics Consortium (TBSGC)

Function and Biology Details

Reaction catalysed: 
ATP + GMP = ADP + GDP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161738 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanylate kinase Chain: A
Molecule details ›
Chain: A
Length: 228 amino acids
Theoretical weight: 24.29 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WKE9 (Residues: 2-208; Coverage: 100%)
Gene names: MTCY21B4.06, Rv1389, gmk
Sequence domains: Guanylate kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CL 1 x CL
Ligand FMT 3 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-D
Spacegroup: I23
Unit cell:
a: 112.126Å b: 112.126Å c: 112.126Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.177 0.231
Expression system: Escherichia coli

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