› 1s4z

Solution NMR

HP1 chromo shadow domain in complex with PXVXL motif of CAF-1

Released:
DOI: 10.2210/pdb1s4z/pdb
PDB entry 1s4z coloured by chain, ensemble of 25 models, front view.
PDB entry 1s4z coloured by chain, ensemble of 25 models, side view.
PDB entry 1s4z coloured by chain, ensemble of 25 models, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin.
Thiru A, Nietlispach D, Mott HR, Okuwaki M, Lyon D, Nielsen PR, Hirshberg M, Verreault A, Murzina NV, Laue ED
EMBO J 23 489-99 (2004)
PMID: 14765118

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160776 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Chromobox protein homolog 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 75 amino acids
Theoretical weight: 8.63 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P83917 (Residues: 104-176; Coverage: 40%)
Gene names: Cbx, Cbx1
Sequence domains: Chromo shadow domain
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Chromatin assembly factor 1 subunit A Chain: C
Molecule details ›
Chain: C
Length: 30 amino acids
Theoretical weight: 3.11 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9QWF0 (Residues: 210-238; Coverage: 3%)
Gene names: Caip150, Chaf1a

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: CNS/ARIA1.1
Expression system: Escherichia coli BL21

Quick links

Citations

31 review citations

Histones: annotating chromatin.
Campos et al. (2009)
30 more

13 mentions without citation

Linking Heterochromatin Protein 1 (HP1) to cancer progression.
Dialynas et al. (2008)
12 more