› › Function and Biology

X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: protein phosphorylation
Cellular component: not assigned

Quick links

EC 2.7.12.2: Mitogen-activated protein kinase kinase

Reaction catalysed:
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Systematic name:
ATP:protein phosphotransferase (MAPKKK-activated)
Alternative Name(s):
  • MAP kinase kinase
  • MAP kinase kinase 4
  • MAP kinase kinase 7
  • MAP kinase or ERK kinase
  • MAP2K
  • MAPKK
  • MAPKK1
  • MEK
  • MEK1
  • MEK2
  • MKK
  • MKK2
  • MKK4
  • MKK6
  • MKK7
  • STK27

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 2
The deposited structure of PDB entry 1s9i contains 2 copies of Pfam domain PF00069 (Protein kinase domain) in Dual specificity mitogen-activated protein kinase kinase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 2
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 2
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 2
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 2

Structure domains

CATH CATH domains
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 2
The deposited structure of PDB entry 1s9i contains 2 copies of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Dual specificity mitogen-activated protein kinase kinase 2. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 2
The deposited structure of PDB entry 1s9i contains 2 copies of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Dual specificity mitogen-activated protein kinase kinase 2. Showing 1 copy in chain A.
SCOP SCOP annotation
88854
Class: Alpha and beta proteins (a+b)
Fold: Protein kinase-like (PK-like)
Superfamily: Protein kinase-like (PK-like)
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 2
The deposited structure of PDB entry 1s9i contains 2 copies of SCOP domain 88854 (Protein kinases, catalytic subunit) in Dual specificity mitogen-activated protein kinase kinase 2. Showing 1 copy in chain A.

Quick links