› › Structure analysis

Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site

X-ray diffraction
3.1Å resolution
PDB entry 1s9k coloured by chain, front view.
PDB entry 1s9k coloured by chain, side view.
PDB entry 1s9k coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 3 distinct polypeptide molecules
2 distinct DNA molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: AP-1 transcription factor complex FOS-JUN-NFATC2 and DNA
hide full assembly name
Multimeric state: hetero pentamer
Accessible surface area: 27111.98 Å2
Buried surface area: 9399.98 Å2
Dissociation area: 1,924.14 Å2
Dissociation energy (ΔGdiss): 18.14 kcal/mol
Dissociation entropy (TΔSdiss): 12.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-114582

Macromolecules

Nuclear factor of activated T-cells, cytoplasmic 2
Chain: C
Length: 280 amino acids
Theoretical weight: 31.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13469 (Residues: 399-678; Coverage: 30%)
Gene names: NFAT1, NFATC2, NFATP
Pfam:
InterPro:
CATH:
SCOP:
Nuclear factor of activated T-cells, cytoplasmic 2 in PDB entry 1s9k, assembly 1, front view.
Nuclear factor of activated T-cells, cytoplasmic 2 in PDB entry 1s9k, assembly 1, side view.
Nuclear factor of activated T-cells, cytoplasmic 2 in PDB entry 1s9k, assembly 1, top view.
Molecule details ›

Search similar proteins

Protein c-Fos
Chain: D
Length: 53 amino acids
Theoretical weight: 6.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01100 (Residues: 140-192; Coverage: 14%)
Gene names: FOS, G0S7
Pfam: bZIP transcription factor
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
SCOP: Leucine zipper domain
Protein c-Fos in PDB entry 1s9k, assembly 1, front view.
Protein c-Fos in PDB entry 1s9k, assembly 1, side view.
Protein c-Fos in PDB entry 1s9k, assembly 1, top view.
Molecule details ›

Search similar proteins

Transcription factor Jun
Chain: E
Length: 52 amino acids
Theoretical weight: 6.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05412 (Residues: 257-308; Coverage: 16%)
Gene name: JUN
Pfam: bZIP transcription factor
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
SCOP: Leucine zipper domain
Transcription factor Jun in PDB entry 1s9k, assembly 1, front view.
Transcription factor Jun in PDB entry 1s9k, assembly 1, side view.
Transcription factor Jun in PDB entry 1s9k, assembly 1, top view.
Molecule details ›

Search similar proteins

DNA chain A
Name: Human IL-2 ARRE1 Promoter Element, Plus Strand
Representative chains: A
Length: 20 nucleotides
Theoretical weight: 6.21 KDa
Human IL-2 ARRE1 Promoter Element, Plus Strand in PDB entry 1s9k, assembly 1, front view.
Human IL-2 ARRE1 Promoter Element, Plus Strand in PDB entry 1s9k, assembly 1, side view.
Human IL-2 ARRE1 Promoter Element, Plus Strand in PDB entry 1s9k, assembly 1, top view.
Molecule details ›

Search similar DNA

DNA chain B
Name: Human IL-2 ARRE1 Promoter Element, Minus Strand
Representative chains: B
Length: 20 nucleotides
Theoretical weight: 6.05 KDa
Human IL-2 ARRE1 Promoter Element, Minus Strand in PDB entry 1s9k, assembly 1, front view.
Human IL-2 ARRE1 Promoter Element, Minus Strand in PDB entry 1s9k, assembly 1, side view.
Human IL-2 ARRE1 Promoter Element, Minus Strand in PDB entry 1s9k, assembly 1, top view.
Molecule details ›

Search similar DNA

Quick links