› 1sbj

Solution NMR

NMR Structure of the Mg2+-loaded C Terminal Domain of Cardiac Troponin C Bound to the N Terminal Domain of Cardiac Troponin I

Released:
DOI: 10.2210/pdb1sbj/pdb
PDB entry 1sbj coloured by chain, ensemble of 20 models, front view.
PDB entry 1sbj coloured by chain, ensemble of 20 models, side view.
PDB entry 1sbj coloured by chain, ensemble of 20 models, top view.
Source organism: Gallus gallus
Primary publication:
Structure of the Mg2+-loaded C-lobe of cardiac troponin C bound to the N-domain of cardiac troponin I: comparison with the Ca2+-loaded structure.
Finley NL, Howarth JW, Rosevear PR
Biochemistry 43 11371-9 (2004)
PMID: 15350124

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140775 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, slow skeletal and cardiac muscles Chain: A
Molecule details ›
Chain: A
Length: 81 amino acids
Theoretical weight: 9.46 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09860 (Residues: 81-161; Coverage: 50%)
Gene name: TNNC1
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DGSA
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Structural based insights into the role of troponin in cardiac muscle pathophysiology.
Li et al. (2004)
3 more

2 mentions without citation

A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy.
Pinto et al. (2009)
1 more