› 1sco

Solution NMR

SCORPION TOXIN (OSK1 TOXIN) WITH HIGH AFFINITY FOR SMALL CONDUCTANCE CA(2+)-ACTIVATED K+ CHANNEL IN NEUROBLASTOMA-X-GLUOMA NG 108-15 HYBRID CELLS, NMR, 30 STRUCTURES

Released:
DOI: 10.2210/pdb1sco/pdb
PDB entry 1sco coloured by chain, ensemble of 30 models, front view.
PDB entry 1sco coloured by chain, ensemble of 30 models, side view.
PDB entry 1sco coloured by chain, ensemble of 30 models, top view.
Source organism: Orthochirus scrobiculosus
Primary publication:
Three-dimensional structure of toxin OSK1 from Orthochirus scrobiculosus scorpion venom.
Jaravine VA, Nolde DE, Reibarkh MJ, Korolkova YV, Kozlov SA, Pluzhnikov KA, Grishin EV, Arseniev AS
Biochemistry 36 1223-32 (1997)
PMID: 9063870

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157341 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel toxin alpha-KTx 3.7 Chain: A
Molecule details ›
Chain: A
Length: 38 amino acids
Theoretical weight: 4.22 KDa
Source organism: Orthochirus scrobiculosus
UniProt:
  • Canonical: P55896 (Residues: 1-38; Coverage: 100%)
Sequence domains: Scorpion short toxin, BmKK2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores

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Citations

3 review citations

Mass spectrometry strategies for venom mapping and peptide sequencing from crude venoms: case applications with single arthropod specimen.
Favreau et al. (2006)
2 more

12 mentions without citation

Kv1.3 Channel as a Key Therapeutic Target for Neuroinflammatory Diseases: State of the Art and Beyond.
Wang et al. (2019)
11 more