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COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB

X-ray diffraction
2.7Å resolution
PDB entry 1seb coloured by chain, front view.
PDB entry 1seb coloured by chain, side view.
PDB entry 1seb coloured by chain, top view.
Source organisms:
Assembly composition:
hetero octamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero octamer
Accessible surface area: 52307.35 Å2
Buried surface area: 18140.83 Å2
Dissociation area: 961.34 Å2
Dissociation energy (ΔGdiss): -6.29 kcal/mol
Dissociation entropy (TΔSdiss): 15.33 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-134376

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chains: A, E
Length: 181 amino acids
Theoretical weight: 21.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01903 (Residues: 26-206; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1seb, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1seb, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1seb, assembly 1, top view.
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HLA class II histocompatibility antigen, DRB1 beta chain
Chains: B, F
Length: 192 amino acids
Theoretical weight: 22.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01911 (Residues: 30-221; Coverage: 81%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1seb, assembly 1, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1seb, assembly 1, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1seb, assembly 1, top view.
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ENDOGENOUS PEPTIDE MODEL, POLY-ALA
Chains: C, G
Length: 13 amino acids
Theoretical weight: 1.12 KDa
Source organism: Homo sapiens
ENDOGENOUS PEPTIDE MODEL, POLY-ALA in PDB entry 1seb, assembly 1, front view.
ENDOGENOUS PEPTIDE MODEL, POLY-ALA in PDB entry 1seb, assembly 1, side view.
ENDOGENOUS PEPTIDE MODEL, POLY-ALA in PDB entry 1seb, assembly 1, top view.
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Enterotoxin type B
Chains: D, H
Length: 234 amino acids
Theoretical weight: 27.79 KDa
Source organism: Staphylococcus aureus
UniProt:
  • Canonical: P01552 (Residues: 29-262; Coverage: 98%)
Gene name: entB
Pfam:
InterPro:
CATH:
SCOP:
Enterotoxin type B in PDB entry 1seb, assembly 1, front view.
Enterotoxin type B in PDB entry 1seb, assembly 1, side view.
Enterotoxin type B in PDB entry 1seb, assembly 1, top view.
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