Function and Biology Details
Reaction catalysed:
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- DNA topoisomerase I
- DNA topoisomerase I, catalytic core, eukaryotic-type
- DNA topoisomerase I, active site
- Topoisomerase I C-terminal domain
- DNA topoisomerase I, catalytic core, alpha/beta subdomain
- DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
- DNA breaking-rejoining enzyme, catalytic core
- DNA topoisomerase I, eukaryotic-type
5 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
DNA topoisomerase 1 and DNA (preferred)
PDBe Complex ID:
PDB-CPX-114589 (preferred)
Entry contents:
1 distinct polypeptide molecule
3 distinct DNA molecules
3 distinct DNA molecules
Macromolecules (4 distinct):
DNA topoisomerase 1
Molecule details ›
Chain: A
Length: 592 amino acids
Theoretical weight: 70.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 592 amino acids
Theoretical weight: 70.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P11387 (Residues: 174-765; Coverage: 77%)
Sequence domains:
- Eukaryotic DNA topoisomerase I, DNA binding fragment
- Eukaryotic DNA topoisomerase I, catalytic core
- C-terminal topoisomerase domain
