› 1shu

X-ray diffraction
1.5Å resolution

Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor

Released:
DOI: 10.2210/pdb1shu/pdb
PDB entry 1shu coloured by chain, front view.
PDB entry 1shu coloured by chain, side view.
PDB entry 1shu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor.
Lacy DB, Wigelsworth DJ, Scobie HM, Young JA, Collier RJ
Proc Natl Acad Sci U S A 101 6367-72 (2004)
PMID: 15079089

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157673 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anthrax toxin receptor 2 Chain: X
Molecule details ›
Chain: X
Length: 182 amino acids
Theoretical weight: 19.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P58335 (Residues: 38-218; Coverage: 40%)
Gene names: ANTXR2, CMG2
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P41212
Unit cell:
a: 57.419Å b: 57.419Å c: 111.459Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.215
Expression system: Escherichia coli BL21(DE3)

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Citations

18 review citations

Anthrax toxin: receptor binding, internalization, pore formation, and translocation.
Young et al. (2007)
17 more

15 mentions without citation

Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation.
Lacy et al. (2004)
14 more