› 1siq

X-ray diffraction
2.1Å resolution

The Crystal Structure and Mechanism of Human Glutaryl-CoA Dehydrogenase

Released:
DOI: 10.2210/pdb1siq/pdb
PDB entry 1siq coloured by chain, front view.
PDB entry 1siq coloured by chain, side view.
PDB entry 1siq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions.
Fu Z, Wang M, Paschke R, Rao KS, Frerman FE, Kim JJ
Biochemistry 43 9674-84 (2004)
PMID: 15274622

Function and Biology Details

Reaction catalysed: 
(1a) glutaryl-CoA + electron-transfer flavoprotein = (E)-glutaconyl-CoA + reduced electron-transfer flavoprotein
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187820 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutaryl-CoA dehydrogenase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 392 amino acids
Theoretical weight: 43.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q92947 (Residues: 47-438; Coverage: 90%)
Gene name: GCDH
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 1 x FAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P6422
Unit cell:
a: 116.96Å b: 116.96Å c: 128.02Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.198 0.223

Quick links

Citations

6 review citations

Anaerobic catabolism of aromatic compounds: a genetic and genomic view.
Carmona et al. (2009)
5 more

11 mentions without citation

Identification and characterization of new long chain acyl-CoA dehydrogenases.
He et al. (2011)
10 more