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HLA-DR1 complexed with a 13 residue HIV capsid peptide

X-ray diffraction
2.25Å resolution
PDB entry 1sjh coloured by chain, front view.
PDB entry 1sjh coloured by chain, side view.
PDB entry 1sjh coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 28206.56 Å2
Buried surface area: 8150.03 Å2
Dissociation area: 582.96 Å2
Dissociation energy (ΔGdiss): -2.18 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135326

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chain: A
Length: 180 amino acids
Theoretical weight: 20.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01903 (Residues: 28-207; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1sjh, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1sjh, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1sjh, assembly 1, top view.
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HLA class II histocompatibility antigen, DRB1 beta chain
Chain: B
Length: 190 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01911 (Residues: 30-219; Coverage: 80%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1sjh, assembly 1, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1sjh, assembly 1, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1sjh, assembly 1, top view.
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Capsid protein p24
Chain: C
Length: 13 amino acids
Theoretical weight: 1.38 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P12495 (Residues: 167-179; Coverage: 3%)
Gene name: gag
Capsid protein p24 in PDB entry 1sjh, assembly 1, front view.
Capsid protein p24 in PDB entry 1sjh, assembly 1, side view.
Capsid protein p24 in PDB entry 1sjh, assembly 1, top view.
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Enterotoxin type C-3
Chain: D
Length: 239 amino acids
Theoretical weight: 27.72 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A0L5 (Residues: 28-266; Coverage: 100%)
Gene name: entC3
Pfam:
InterPro:
CATH:
SCOP:
Enterotoxin type C-3 in PDB entry 1sjh, assembly 1, front view.
Enterotoxin type C-3 in PDB entry 1sjh, assembly 1, side view.
Enterotoxin type C-3 in PDB entry 1sjh, assembly 1, top view.
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