› 1sjq

Solution NMR

NMR Structure of RRM1 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1)

Released:
DOI: 10.2210/pdb1sjq/pdb
PDB entry 1sjq coloured by chain, ensemble of 16 models, front view.
PDB entry 1sjq coloured by chain, ensemble of 16 models, side view.
PDB entry 1sjq coloured by chain, ensemble of 16 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and RNA interactions of the N-terminal RRM domains of PTB.
Simpson PJ, Monie TP, Szendröi A, Davydova N, Tyzack JK, Conte MR, Read CM, Cary PD, Svergun DI, Konarev PV, Curry S, Matthews S
Structure 12 1631-43 (2004)
PMID: 15341728

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150779 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polypyrimidine tract-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26599 (Residues: 55-147; Coverage: 17%)
Gene names: PTB, PTBP1
Sequence domains: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Hybrid distance geometry/simulated annealing
Expression system: Escherichia coli

Quick links

Citations

10 review citations

The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression.
Maris et al. (2005)
9 more

9 mentions without citation

Reviewing PTBP1 Domain Modularity in the Pre-Genomic Era: A Foundation to Guide the Next Generation of Exploring PTBP1 Structure-Function Relationships.
Carico et al. (2023)
8 more