› 1sju

Solution NMR

MINI-PROINSULIN, SINGLE CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP AND PEPTIDE BOND BETWEEN LYS B 29 AND GLY A 1, NMR, 20 STRUCTURES

Released:
DOI: 10.2210/pdb1sju/pdb
PDB entry 1sju coloured by chain, ensemble of 20 models, front view.
PDB entry 1sju coloured by chain, ensemble of 20 models, side view.
PDB entry 1sju coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
Hua QX, Hu SQ, Jia W, Chu YC, Burke GT, Wang SH, Wang RY, Katsoyannis PG, Weiss MA
J Mol Biol 277 103-18 (1998)
PMID: 9514738

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134181 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin B chain Chain: A
Molecule details ›
Chain: A
Length: 50 amino acids
Theoretical weight: 5.69 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-110; Coverage: 58%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family
Structure domains: Insulin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

4 review citations

Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer.
Clemmons DR. (2007)
3 more

1 mention without citation

Predicting Designability of Small Proteins from Graph Features of Contact Maps.
Leelananda et al. (2016)