1sug

X-ray diffraction
1.95Å resolution

1.95 A structure of apo protein tyrosine phosphatase 1B

Released:
Source organism: Homo sapiens
Primary publication:
Water-molecule network and active-site flexibility of apo protein tyrosine phosphatase 1B.
Acta Crystallogr D Biol Crystallogr 60 1527-34 (2004)
PMID: 15333922

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-148259 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 1 Chain: A
Molecule details ›
Chain: A
Length: 321 amino acids
Theoretical weight: 37.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P18031 (Residues: 1-321; Coverage: 74%)
Gene names: PTP1B, PTPN1
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P3121
Unit cell:
a: 88.118Å b: 88.118Å c: 103.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.188 0.203
Expression system: Escherichia coli BL21(DE3)