› 1sxe

Solution NMR

The solution structure of the Pointed (PNT) domain from the transcrition factor Erg

Released:
DOI: 10.2210/pdb1sxe/pdb
PDB entry 1sxe coloured by chain, ensemble of 14 models, front view.
PDB entry 1sxe coloured by chain, ensemble of 14 models, side view.
PDB entry 1sxe coloured by chain, ensemble of 14 models, top view.
Source organism: Homo sapiens
Primary publication:
Diversity in structure and function of the Ets family PNT domains.
Mackereth CD, Schärpf M, Gentile LN, MacIntosh SE, Slupsky CM, McIntosh LP
J Mol Biol 342 1249-64 (2004)
PMID: 15351649

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145750 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional regulator ERG Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 11.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11308 (Residues: 108-201; Coverage: 20%)
Gene name: ERG
Sequence domains: Sterile alpha motif (SAM)/Pointed domain
Structure domains: Transcription Factor, Ets-1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

The many faces of the helix-turn-helix domain: transcription regulation and beyond.
Aravind et al. (2005)
10 more

3 mentions without citation

Genomic and biochemical insights into the specificity of ETS transcription factors.
Hollenhorst et al. (2011)
2 more