› 1t0c

Solution NMR

Solution Structure of Human Proinsulin C-Peptide

Released:
DOI: 10.2210/pdb1t0c/pdb
PDB entry 1t0c coloured by chain, ensemble of 30 models, front view.
PDB entry 1t0c coloured by chain, ensemble of 30 models, side view.
PDB entry 1t0c coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of human proinsulin C-peptide.
Munte CE, Vilela L, Kalbitzer HR, Garratt RC
FEBS J 272 4284-93 (2005)
PMID: 16098208

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134181 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin Chain: A
Molecule details ›
Chain: A
Length: 31 amino acids
Theoretical weight: 3.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01308 (Residues: 57-87; Coverage: 36%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Simulated annealing, torsion-angle dynamics, Powell minimisation
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Implications of peptide assemblies in amyloid diseases.
Ke et al. (2017)
4 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)