› 1t2m

Solution NMR

Solution Structure Of The Pdz Domain Of AF-6

Released:
DOI: 10.2210/pdb1t2m/pdb
PDB entry 1t2m coloured by chain, ensemble of 20 models, front view.
PDB entry 1t2m coloured by chain, ensemble of 20 models, side view.
PDB entry 1t2m coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr.
Zhou H, Xu Y, Yang Y, Huang A, Wu J, Shi Y
J Biol Chem 280 13841-7 (2005)
PMID: 15684424

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157211 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Afadin Chain: A
Molecule details ›
Chain: A
Length: 101 amino acids
Theoretical weight: 10.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55196 (Residues: 1003-1094; Coverage: 5%)
Gene names: AF6, AFDN, MLLT4
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Adhesion molecules in the nervous system: structural insights into function and diversity.
Shapiro et al. (2007)
3 more

2 mentions without citation

Crystal structure of afadin PDZ domain-nectin-3 complex shows the structural plasticity of the ligand-binding site.
Fujiwara et al. (2015)
1 more