› › Structure analysis

HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR)

X-ray diffraction
2.4Å resolution
PDB entry 1t5w coloured by chain, front view.
PDB entry 1t5w coloured by chain, side view.
PDB entry 1t5w coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1
Download    3D Visualisation
Multimeric state: hetero trimer
Accessible surface area: 17899.24 Å2
Buried surface area: 7319.34 Å2
Dissociation area: 1,219.1 Å2
Dissociation energy (ΔGdiss): 14.6 kcal/mol
Dissociation entropy (TΔSdiss): 8.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135335
Assembly 2 (preferred)
Download    3D Visualisation
Multimeric state: hetero trimer
Accessible surface area: 17692.46 Å2
Buried surface area: 7327.03 Å2
Dissociation area: 1,217.67 Å2
Dissociation energy (ΔGdiss): 14.56 kcal/mol
Dissociation entropy (TΔSdiss): 8.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135335

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chains: A, D
Length: 180 amino acids
Theoretical weight: 20.97 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01903 (Residues: 27-206; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1t5w, assembly 2, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1t5w, assembly 2, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1t5w, assembly 2, top view.
Molecule details ›

Search similar proteins

HLA class II histocompatibility antigen, DRB1 beta chain
Chains: B, E
Length: 190 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01911 (Residues: 30-219; Coverage: 80%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1t5w, assembly 2, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1t5w, assembly 2, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1t5w, assembly 2, top view.
Molecule details ›

Search similar proteins

Regulatory protein MIG1
Chains: C, F
Length: 15 amino acids
Theoretical weight: 1.6 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Not provided
UniProt:
  • Canonical: P27705 (Residues: 455-462; Coverage: 2%)
Gene names: CAT4, MIG1, SSN1, YGL035C
Regulatory protein MIG1 in PDB entry 1t5w, assembly 2, front view.
Regulatory protein MIG1 in PDB entry 1t5w, assembly 2, side view.
Regulatory protein MIG1 in PDB entry 1t5w, assembly 2, top view.
Molecule details ›

Search similar proteins

Quick links