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HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR) and the superantigen SEC3-3B2

X-ray diffraction
2.5Å resolution
PDB entry 1t5x coloured by chain, front view.
PDB entry 1t5x coloured by chain, side view.
PDB entry 1t5x coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 28066.12 Å2
Buried surface area: 8400.29 Å2
Dissociation area: 611.77 Å2
Dissociation energy (ΔGdiss): -2.28 kcal/mol
Dissociation entropy (TΔSdiss): 13.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135327

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chain: A
Length: 181 amino acids
Theoretical weight: 21.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01903 (Residues: 27-207; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1t5x, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1t5x, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1t5x, assembly 1, top view.
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HLA class II histocompatibility antigen, DRB1 beta chain
Chain: B
Length: 190 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01911 (Residues: 30-219; Coverage: 80%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1t5x, assembly 1, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1t5x, assembly 1, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1t5x, assembly 1, top view.
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Regulatory protein MIG1
Chain: C
Length: 15 amino acids
Theoretical weight: 1.6 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Not provided
UniProt:
  • Canonical: P27705 (Residues: 455-462; Coverage: 2%)
Gene names: CAT4, MIG1, SSN1, YGL035C
Regulatory protein MIG1 in PDB entry 1t5x, assembly 1, front view.
Regulatory protein MIG1 in PDB entry 1t5x, assembly 1, side view.
Regulatory protein MIG1 in PDB entry 1t5x, assembly 1, top view.
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Enterotoxin type C-3
Chain: D
Length: 239 amino acids
Theoretical weight: 27.72 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A0L5 (Residues: 28-266; Coverage: 100%)
Gene name: entC3
Pfam:
InterPro:
CATH:
SCOP:
Enterotoxin type C-3 in PDB entry 1t5x, assembly 1, front view.
Enterotoxin type C-3 in PDB entry 1t5x, assembly 1, side view.
Enterotoxin type C-3 in PDB entry 1t5x, assembly 1, top view.
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