› 1t95

X-ray diffraction
1.9Å resolution

Crystal Structure of the Shwachman-Bodian-Diamond Syndrome Protein Orthologue from Archaeoglobus fulgidus

Released:
DOI: 10.2210/pdb1t95/pdb
PDB entry 1t95 coloured by chain, front view.
PDB entry 1t95 coloured by chain, side view.
PDB entry 1t95 coloured by chain, top view.
Source organism: Archaeoglobus fulgidus
Primary publication:
Structural and mutational analysis of the SBDS protein family. Insight into the leukemia-associated Shwachman-Diamond Syndrome.
Shammas C, Menne TF, Hilcenko C, Michell SR, Goyenechea B, Boocock GR, Durie PR, Rommens JM, Warren AJ
J Biol Chem 280 19221-9 (2005)
PMID: 15701631

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128165 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosome maturation protein SDO1 homolog Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 27.72 KDa
Source organism: Archaeoglobus fulgidus
Expression system: Escherichia coli
UniProt:
  • Canonical: O29759 (Residues: 2-234; Coverage: 100%)
Gene name: AF_0491
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P1
Unit cell:
a: 33.668Å b: 44.448Å c: 54.72Å
α: 75.87° β: 85.61° γ: 69.49°
R-values:
R R work R free
0.255 0.212 0.249
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Pathophysiology and management of inherited bone marrow failure syndromes.
Shimamura et al. (2010)
18 more

2 mentions without citation

Conformational flexibility and molecular interactions of an archaeal homologue of the Shwachman-Bodian-Diamond syndrome protein.
Ng et al. (2009)
1 more