› 1tij

X-ray diffraction
3.03Å resolution

3D Domain-swapped human cystatin C with amyloid-like intermolecular beta-sheets

Released:
DOI: 10.2210/pdb1tij/pdb
PDB entry 1tij coloured by chain, front view.
PDB entry 1tij coloured by chain, side view.
PDB entry 1tij coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
3D domain-swapped human cystatin C with amyloidlike intermolecular beta-sheets.
Janowski R, Kozak M, Abrahamson M, Grubb A, Jaskolski M
Proteins 61 570-8 (2005)
PMID: 16170782

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133889 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystatin-C Chains: A, B
Molecule details ›
Chains: A, B
Length: 120 amino acids
Theoretical weight: 13.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01034 (Residues: 27-146; Coverage: 100%)
Gene name: CST3
Sequence domains: Cystatin domain
Structure domains: Nuclear Transport Factor 2; Chain: A,

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7A
Spacegroup: P41212
Unit cell:
a: 91.49Å b: 91.49Å c: 144.45Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.217 0.262
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade.
Chiti et al. (2017)
11 more

13 mentions without citation

Protein acrobatics in pairs--dimerization via domain swapping.
Gronenborn AM. (2009)
12 more