› 1tki

X-ray diffraction
2Å resolution

AUTOINHIBITED SERINE KINASE DOMAIN OF THE GIANT MUSCLE PROTEIN TITIN

Released:
DOI: 10.2210/pdb1tki/pdb
PDB entry 1tki coloured by chain, front view.
PDB entry 1tki coloured by chain, side view.
PDB entry 1tki coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for activation of the titin kinase domain during myofibrillogenesis.
Mayans O, van der Ven PF, Wilm M, Mues A, Young P, Fürst DO, Wilmanns M, Gautel M
Nature 395 863-9 (1998)
PMID: 9804419

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Titin Chains: A, B
Molecule details ›
Chains: A, B
Length: 321 amino acids
Theoretical weight: 37.17 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8WZ42 (Residues: 32172-32492; Coverage: 1%)
Gene name: TTN
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P212121
Unit cell:
a: 78.61Å b: 89.77Å c: 113.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 0.248
Expression system: Spodoptera frugiperda

Quick links

Citations

67 review citations

The conformational plasticity of protein kinases.
Huse et al. (2002)
66 more

18 mentions without citation

Cytoskeletal protein kinases: titin and its relations in mechanosensing.
Gautel M. (2011)
17 more