› 1tnf

X-ray diffraction
2.6Å resolution

THE STRUCTURE OF TUMOR NECROSIS FACTOR-ALPHA AT 2.6 ANGSTROMS RESOLUTION. IMPLICATIONS FOR RECEPTOR BINDING

Released:
DOI: 10.2210/pdb1tnf/pdb
PDB entry 1tnf coloured by chain, front view.
PDB entry 1tnf coloured by chain, side view.
PDB entry 1tnf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
Eck MJ, Sprang SR
J Biol Chem 264 17595-605 (1989)
PMID: 2551905

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134285 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor, soluble form Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 157 amino acids
Theoretical weight: 17.37 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01375 (Residues: 77-233; Coverage: 67%)
Gene names: TNF, TNFA, TNFSF2
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 95Å b: 95Å c: 117Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.23 not available
Expression system: Not provided

Quick links

Citations

73 review citations

The TNF and TNF receptor superfamilies: integrating mammalian biology.
Locksley et al. (2001)
72 more

97 mentions without citation

In silico structure-based approaches to discover protein-protein interaction-targeting drugs.
Shin et al. (2017)
96 more