› 1tpg

Solution NMR

F1-G MODULE PAIR RESIDUES 1-91 (C83S) OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA) (NMR, 298K, PH2.95, REPRESENTATIVE STRUCTURE)

Released:
DOI: 10.2210/pdb1tpg/pdb
PDB entry 1tpg coloured by chain, front view.
PDB entry 1tpg coloured by chain, side view.
PDB entry 1tpg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator.
Smith BO, Downing AK, Driscoll PC, Dudgeon TJ, Campbell ID
Structure 3 823-33 (1995)
PMID: 7582899

Function and Biology Details

Reaction catalysed: 
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133299 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tissue-type plasminogen activator chain A Chain: A
Molecule details ›
Chain: A
Length: 91 amino acids
Theoretical weight: 10.46 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P00750 (Residues: 36-126; Coverage: 17%)
Gene name: PLAT
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Saccharomyces cerevisiae

Quick links

Citations

7 review citations

Structure and distribution of modules in extracellular proteins.
Bork et al. (1996)
6 more

6 mentions without citation

Structural Biology and Protein Engineering of Thrombolytics.
Mican et al. (2019)
5 more