› 1tph

X-ray diffraction
1.8Å resolution

1.8 ANGSTROMS CRYSTAL STRUCTURE OF WILD TYPE CHICKEN TRIOSEPHOSPHATE ISOMERASE-PHOSPHOGLYCOLOHYDROXAMATE COMPLEX

Released:
DOI: 10.2210/pdb1tph/pdb
PDB entry 1tph coloured by chain, front view.
PDB entry 1tph coloured by chain, side view.
PDB entry 1tph coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Crystal structure of recombinant chicken triosephosphate isomerase-phosphoglycolohydroxamate complex at 1.8-A resolution.
Zhang Z, Sugio S, Komives EA, Liu KD, Knowles JR, Petsko GA, Ringe D
Biochemistry 33 2830-7 (1994)
PMID: 8130195

Function and Biology Details

Reactions catalysed: 
Glycerone phosphate = methylglyoxal + phosphate
D-glyceraldehyde 3-phosphate = glycerone phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133701 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Triosephosphate isomerase Chains: 1, 2
Molecule details ›
Chains: 1, 2
Length: 247 amino acids
Theoretical weight: 26.54 KDa
Source organism: Gallus gallus
Expression system: Not provided
UniProt:
  • Canonical: P00940 (Residues: 2-248; Coverage: 100%)
Gene name: TPI1
Sequence domains: Triosephosphate isomerase
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:
Ligand PGH 2 x PGH
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 136.4Å b: 74Å c: 57.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 not available not available
Expression system: Not provided

Quick links

Citations

3 review citations

Triosephosphate isomerase: a highly evolved biocatalyst.
Wierenga et al. (2010)
2 more

25 mentions without citation

A role for flexible loops in enzyme catalysis.
Malabanan et al. (2010)
24 more