› 1txu

X-ray diffraction
2.35Å resolution

Crystal Structure of the Vps9 Domain of Rabex-5

Released:
DOI: 10.2210/pdb1txu/pdb
PDB entry 1txu coloured by chain, front view.
PDB entry 1txu coloured by chain, side view.
PDB entry 1txu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5.
Delprato A, Merithew E, Lambright DG
Cell 118 607-17 (2004)
PMID: 15339665

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rab5 GDP/GTP exchange factor Chain: A
Molecule details ›
Chain: A
Length: 273 amino acids
Theoretical weight: 32.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UJ41 (Residues: 131-394; Coverage: 54%)
Gene names: RABEX5, RABGEF1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
1 modified residue:
Ligand MSE 9 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12B
Spacegroup: P21212
Unit cell:
a: 68.047Å b: 88.329Å c: 47.299Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.227 0.269
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

23 review citations

Rab GTPases as coordinators of vesicle traffic.
Stenmark H. (2009)
22 more

8 mentions without citation

Protein-protein docking benchmark version 3.0.
Hwang et al. (2008)
7 more