› 1u39

Solution NMR

Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains

Released:
DOI: 10.2210/pdb1u39/pdb
PDB entry 1u39 coloured by chain, ensemble of 20 models, front view.
PDB entry 1u39 coloured by chain, ensemble of 20 models, side view.
PDB entry 1u39 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem.
Long JF, Feng W, Wang R, Chan LN, Ip FC, Xia J, Ip NY, Zhang M
Nat Struct Mol Biol 12 722-8 (2005)
PMID: 16007100

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169718 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta A4 precursor protein-binding family A member 1 Chain: A
Molecule details ›
Chain: A
Length: 80 amino acids
Theoretical weight: 8.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02410 (Residues: 743-822; Coverage: 10%)
Gene names: APBA1, MINT1, X11
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density.
Feng et al. (2009)
12 more

2 mentions without citation

Domain swapping within PDZ2 is responsible for dimerization of ZO proteins.
Fanning et al. (2007)
1 more