› 1u4p

X-ray diffraction
1.7Å resolution

Crystal Structure of human RANTES mutant K45E

Released:
DOI: 10.2210/pdb1u4p/pdb
PDB entry 1u4p coloured by chain, front view.
PDB entry 1u4p coloured by chain, side view.
PDB entry 1u4p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The X-ray structure of RANTES: heparin-derived disaccharides allows the rational design of chemokine inhibitors.
Shaw JP, Johnson Z, Borlat F, Zwahlen C, Kungl A, Roulin K, Harrenga A, Wells TN, Proudfoot AE
Structure 12 2081-93 (2004)
PMID: 15530372

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146622 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C motif chemokine 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 68 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P13501 (Residues: 24-91; Coverage: 100%)
Gene names: CCL5, D17S136E, SCYA5
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

1 bound ligand:
Ligand ACY 1 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: P212121
Unit cell:
a: 29.687Å b: 58.49Å c: 72.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.206 0.254
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

23 review citations

Chemokine: receptor structure, interactions, and antagonism.
Allen et al. (2007)
22 more