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Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the CDC42-associated Tyrosine Kinase ACK1 bound to AMP-PCP

X-ray diffraction
2.8Å resolution
PDB entry 1u54 coloured by chain, front view.
PDB entry 1u54 coloured by chain, side view.
PDB entry 1u54 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Activated CDC42 kinase 1
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Multimeric state: monomeric
Accessible surface area: 13020.95 Å2
Buried surface area: 1023.06 Å2
Dissociation area: 127.63 Å2
Dissociation energy (ΔGdiss): 16.09 kcal/mol
Dissociation entropy (TΔSdiss): 0.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170563
Assembly 2
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Assembly Name: Activated CDC42 kinase 1
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Multimeric state: monomeric
Accessible surface area: 12962.18 Å2
Buried surface area: 1082.73 Å2
Dissociation area: 461.77 Å2
Dissociation energy (ΔGdiss): 7.94 kcal/mol
Dissociation entropy (TΔSdiss): 5.41 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170563

Macromolecules

Activated CDC42 kinase 1
Chain: A
Length: 291 amino acids
Theoretical weight: 33.14 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q07912 (Residues: 109-395; Coverage: 28%)
Gene names: ACK1, TNK2
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Activated CDC42 kinase 1 in PDB entry 1u54, assembly 1, front view.
Activated CDC42 kinase 1 in PDB entry 1u54, assembly 1, side view.
Activated CDC42 kinase 1 in PDB entry 1u54, assembly 1, top view.
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Activated CDC42 kinase 1
Chain: B
Length: 291 amino acids
Theoretical weight: 33.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q07912 (Residues: 109-395; Coverage: 28%)
Gene names: ACK1, TNK2
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Activated CDC42 kinase 1 in PDB entry 1u54, assembly 2, front view.
Activated CDC42 kinase 1 in PDB entry 1u54, assembly 2, side view.
Activated CDC42 kinase 1 in PDB entry 1u54, assembly 2, top view.
Molecule details ›

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