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NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain

Solution NMR
PDB entry 1u5s coloured by chain, ensemble of 18 models, front view.
PDB entry 1u5s coloured by chain, ensemble of 18 models, side view.
PDB entry 1u5s coloured by chain, ensemble of 18 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cytoplasmic protein NCK2 and LIM and senescent cell antigen-like-containing domain protein 1
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Multimeric state: hetero dimer
Accessible surface area: 9645.99 Å2
Buried surface area: 465.56 Å2
Dissociation area: 232.78 Å2
Dissociation energy (ΔGdiss): -8.68 kcal/mol
Dissociation entropy (TΔSdiss): 9.91 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-129044

Macromolecules

Cytoplasmic protein NCK2
Chain: A
Length: 71 amino acids
Theoretical weight: 8.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43639 (Residues: 192-262; Coverage: 19%)
Gene names: GRB4, NCK2
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
SCOP: SH3-domain
Cytoplasmic protein NCK2 in PDB entry 1u5s, assembly 1, front view.
Cytoplasmic protein NCK2 in PDB entry 1u5s, assembly 1, side view.
Cytoplasmic protein NCK2 in PDB entry 1u5s, assembly 1, top view.
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LIM and senescent cell antigen-like-containing domain protein 1
Chain: B
Length: 66 amino acids
Theoretical weight: 7.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P48059 (Residues: 188-251; Coverage: 20%)
Gene names: LIMS1, PINCH, PINCH1
Pfam: LIM domain
InterPro:
CATH: Cysteine Rich Protein
SCOP: LIM domain
LIM and senescent cell antigen-like-containing domain protein 1 in PDB entry 1u5s, assembly 1, front view.
LIM and senescent cell antigen-like-containing domain protein 1 in PDB entry 1u5s, assembly 1, side view.
LIM and senescent cell antigen-like-containing domain protein 1 in PDB entry 1u5s, assembly 1, top view.
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