1u8c

X-ray diffraction
3.1Å resolution

A novel adaptation of the integrin PSI domain revealed from its crystal structure

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-138434 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Integrin alpha-V Chain: A
Molecule details ›
Chain: A
Length: 957 amino acids
Theoretical weight: 105.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06756 (Residues: 31-987; Coverage: 94%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:
Structure domains:
Integrin beta-3 Chain: B
Molecule details ›
Chain: B
Length: 692 amino acids
Theoretical weight: 76.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P05106 (Residues: 27-718; Coverage: 91%)
Gene names: GP3A, ITGB3
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, NDG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3221
Unit cell:
a: 130Å b: 130Å c: 307.3Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.293 0.293 0.367
Expression system: Spodoptera frugiperda