› 1ucf

X-ray diffraction
1.95Å resolution

The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease

Released:
DOI: 10.2210/pdb1ucf/pdb
PDB entry 1ucf coloured by chain, front view.
PDB entry 1ucf coloured by chain, side view.
PDB entry 1ucf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease.
Honbou K, Suzuki NN, Horiuchi M, Niki T, Taira T, Ariga H, Inagaki F
J Biol Chem 278 31380-4 (2003)
PMID: 12796482

Function and Biology Details

Reaction catalysed: 
An N(6)-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H(2)O = a [protein]-L-lysine + lactate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189207 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Parkinson disease protein 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 189 amino acids
Theoretical weight: 19.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q99497 (Residues: 1-189; Coverage: 100%)
Gene name: PARK7
Sequence domains: DJ-1/PfpI family
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU ULTRAX 18
Spacegroup: P31
Unit cell:
a: 75.039Å b: 75.039Å c: 74.877Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.173 0.17 0.195
Expression system: Escherichia coli BL21

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Citations

32 review citations

Expanding insights of mitochondrial dysfunction in Parkinson's disease.
Abou-Sleiman et al. (2006)
31 more

8 mentions without citation

Bacterial Responses to Glyoxal and Methylglyoxal: Reactive Electrophilic Species.
Lee et al. (2017)
7 more