› 1uhl

X-ray diffraction
2.9Å resolution

Crystal structure of the LXRalfa-RXRbeta LBD heterodimer

Released:
DOI: 10.2210/pdb1uhl/pdb
PDB entry 1uhl coloured by chain, front view.
PDB entry 1uhl coloured by chain, side view.
PDB entry 1uhl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation.
Svensson S, Ostberg T, Jacobsson M, Norström C, Stefansson K, Hallén D, Johansson IC, Zachrisson K, Ogg D, Jendeberg L
EMBO J 22 4625-33 (2003)
PMID: 12970175

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151267 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Retinoic acid receptor RXR-beta Chain: A
Molecule details ›
Chain: A
Length: 236 amino acids
Theoretical weight: 26.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P28702 (Residues: 298-533; Coverage: 44%)
Gene names: NR2B2, RXRB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Oxysterols receptor LXR-alpha Chain: B
Molecule details ›
Chain: B
Length: 242 amino acids
Theoretical weight: 28.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13133 (Residues: 207-447; Coverage: 54%)
Gene names: LXRA, NR1H3
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 10 amino acids
Theoretical weight: 1.28 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 687-696; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

2 bound ligands:
Ligand MEI 1 x MEI
Ligand 444 1 x 444
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P212121
Unit cell:
a: 67.634Å b: 88.996Å c: 90.795Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.219 0.326
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

41 review citations

Liver X receptors as integrators of metabolic and inflammatory signaling.
Zelcer et al. (2006)
40 more

22 mentions without citation

The retinoid X receptors and their ligands.
Dawson et al. (2012)
21 more