› 1uii

X-ray diffraction
2Å resolution

Crystal structure of Geminin coiled-coil domain

Released:
DOI: 10.2210/pdb1uii/pdb
PDB entry 1uii coloured by chain, front view.
PDB entry 1uii coloured by chain, side view.
PDB entry 1uii coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition.
Saxena S, Yuan P, Dhar SK, Senga T, Takeda D, Robinson H, Kornbluth S, Swaminathan K, Dutta A
Mol Cell 15 245-58 (2004)
PMID: 15260975

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130998 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Geminin Chains: A, B
Molecule details ›
Chains: A, B
Length: 83 amino acids
Theoretical weight: 9.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75496 (Residues: 70-152; Coverage: 40%)
Gene name: GMNN
Sequence domains: Geminin
Structure domains: Geminin coiled-coil domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12B, null
Spacegroup: P212121
Unit cell:
a: 37.16Å b: 94.46Å c: 102.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.239
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Preventing re-replication of chromosomal DNA.
Blow et al. (2005)
8 more

7 mentions without citation

How sequence directs bending in tropomyosin and other two-stranded alpha-helical coiled coils.
Brown JH. (2010)
6 more