› 1ujl

Solution NMR

Solution Structure of the HERG K+ channel S5-P extracellular linker

Released:
DOI: 10.2210/pdb1ujl/pdb
PDB entry 1ujl coloured by chain, ensemble of 20 models, front view.
PDB entry 1ujl coloured by chain, ensemble of 20 models, side view.
PDB entry 1ujl coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics.
Vandenberg JI, Torres AM, Campbell TJ, Kuchel PW
Eur Biophys J 33 89-97 (2004)
PMID: 13680209

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171399 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium voltage-gated channel subfamily H member 2 Chain: A
Molecule details ›
Chain: A
Length: 42 amino acids
Theoretical weight: 4.59 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q12809 (Residues: 570-611; Coverage: 4%)
Gene names: ERG, ERG1, HERG, KCNH2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics, distance geometry, torsion angle dynamics
Expression system: Not provided

Quick links

Citations

9 review citations

QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development.
Recanatini et al. (2005)
8 more