› 1upl

X-ray diffraction
2.6Å resolution

Crystal structure of MO25 alpha

Released:
DOI: 10.2210/pdb1upl/pdb
PDB entry 1upl coloured by chain, front view.
PDB entry 1upl coloured by chain, side view.
PDB entry 1upl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor.
Milburn CC, Boudeau J, Deak M, Alessi DR, van Aalten DM
Nat Struct Mol Biol 11 193-200 (2004)
PMID: 14730349

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195185 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium-binding protein 39 Chains: A, B
Molecule details ›
Chains: A, B
Length: 341 amino acids
Theoretical weight: 40.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y376 (Residues: 1-341; Coverage: 100%)
Gene names: CAB39, CGI-66, MO25
Sequence domains: Mo25-like
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 18 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 70.625Å b: 94.012Å c: 96.327Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.28
Expression system: Escherichia coli

Quick links

Citations

13 review citations

LKB1-dependent signaling pathways.
Alessi et al. (2006)
12 more

2 mentions without citation

Updates to the Integrated Protein-Protein Interaction Benchmarks: Docking Benchmark Version 5 and Affinity Benchmark Version 2.
Vreven et al. (2015)
1 more