Function and Biology Details
Reactions catalysed:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
(1a) S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [(E3-independent) E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-monoubiquitinyl-[(E3-independent) ubiquitin-conjugating enzyme]-L-cysteine
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131957 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ubiquitin-conjugating enzyme E2 D2
Molecule details ›
Chain: A
Length: 147 amino acids
Theoretical weight: 16.76 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Ubiquitin-conjugating enzyme
Length: 147 amino acids
Theoretical weight: 16.76 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P62837 (Residues: 1-147; Coverage: 100%)
Sequence domains: Ubiquitin-conjugating enzyme
CCR4-NOT transcription complex subunit 4
Molecule details ›
Chain: B
Length: 52 amino acids
Theoretical weight: 6.15 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: RING/Ubox like zinc-binding domain
Length: 52 amino acids
Theoretical weight: 6.15 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: O95628 (Residues: 12-63; Coverage: 9%)
Sequence domains: RING/Ubox like zinc-binding domain
