› 1uz9

X-ray diffraction
1.6Å resolution

Crystallographic and solution studies of N-lithocholyl insulin: a new generation of prolonged-acting insulins.

Released:
DOI: 10.2210/pdb1uz9/pdb
PDB entry 1uz9 coloured by chain, front view.
PDB entry 1uz9 coloured by chain, side view.
PDB entry 1uz9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallographic and solution studies of N-lithocholyl insulin: a new generation of prolonged-acting human insulins.
Whittingham JL, Jonassen I, Havelund S, Roberts SM, Dodson EJ, Verma CS, Wilkinson AJ, Dodson GG
Biochemistry 43 5987-95 (2004)
PMID: 15147182

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134235 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chain: A
Molecule details ›
Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chain: B
Molecule details ›
Chain: B
Length: 29 amino acids
Theoretical weight: 3.33 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-53; Coverage: 34%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

4 bound ligands:
Ligand CRS 1 x CRS
Ligand UZ9 1 x UZ9
Ligand ZN 1 x ZN
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P6322
Unit cell:
a: 51.79Å b: 51.79Å c: 68.34Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.179 0.206
Expression system: Not provided

Quick links

Citations

5 review citations

Chemically controlled closed-loop insulin delivery.
Ravaine et al. (2008)
4 more

1 mention without citation

Mechanism of Tianma Gouteng Decoction in the treatment of Parkinson's disease based on network pharmacology and molecular docking.
Ni et al. (2023)