› 1v3b

X-ray diffraction
2Å resolution

Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III

Released:
DOI: 10.2210/pdb1v3b/pdb
PDB entry 1v3b coloured by chain, front view.
PDB entry 1v3b coloured by chain, side view.
PDB entry 1v3b coloured by chain, top view.
Source organism: Human respirovirus 3
Primary publication:
Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III.
Lawrence MC, Borg NA, Streltsov VA, Pilling PA, Epa VC, Varghese JN, McKimm-Breschkin JL, Colman PM
J Mol Biol 335 1343-57 (2004)
PMID: 14729348

Function and Biology Details

Reaction catalysed: 
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180497 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Hemagglutinin-neuraminidase glycoprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 431 amino acids
Theoretical weight: 48.11 KDa
Source organism: Human respirovirus 3
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q6WJ03 (Residues: 142-572; Coverage: 75%)
Gene name: HN
Sequence domains: Haemagglutinin-neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 3 x NAG
Ligand CA 2 x CA
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-ID-B, RIGAKU
Spacegroup: P6222
Unit cell:
a: 219.142Å b: 219.142Å c: 109.379Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.182 0.182 0.215
Expression system: Trichoplusia ni

Quick links

Citations

37 review citations

Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme.
White et al. (2008)
36 more

5 mentions without citation

Interaction between the hemagglutinin-neuraminidase and fusion glycoproteins of human parainfluenza virus type III regulates viral growth in vivo.
Xu et al. (2013)
4 more