› 1v8f

X-ray diffraction
1.9Å resolution

Crystal Structure of Pantoate-beta-Alanine (Pantothenate Synthetase) from Thermus Thermophilus HB8

Released:
DOI: 10.2210/pdb1v8f/pdb
PDB entry 1v8f coloured by chain, front view.
PDB entry 1v8f coloured by chain, side view.
PDB entry 1v8f coloured by chain, top view.
Source organism: Thermus thermophilus
Entry authors: Bagautdinov B, Tahirov TH, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-177868 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pantothenate synthetase Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 30.73 KDa
Source organism: Thermus thermophilus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5SHF5 (Residues: 1-276; Coverage: 100%)
Gene names: TTHA1775, panC
Sequence domains: Pantoate-beta-alanine ligase
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand CL 5 x CL
Ligand 144 1 x 144
Ligand P6G 1 x P6G
Ligand GOL 8 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B1
Spacegroup: P6122
Unit cell:
a: 88.514Å b: 88.514Å c: 266.72Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.205 0.257
Expression system: Escherichia coli

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