› 1vac

X-ray diffraction
2.5Å resolution

MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND CHICKEN OVALBUMIN

Released:
DOI: 10.2210/pdb1vac/pdb
PDB entry 1vac coloured by chain, front view.
PDB entry 1vac coloured by chain, side view.
PDB entry 1vac coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove.
Fremont DH, Stura EA, Matsumura M, Peterson PA, Wilson IA
Proc Natl Acad Sci U S A 92 2479-83 (1995)
PMID: 7708669

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-133796 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
H-2 class I histocompatibility antigen, K-B alpha chain Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 31.65 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01901 (Residues: 22-295; Coverage: 79%)
Gene names: H2-K, H2-K1
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.7 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01887 (Residues: 21-119; Coverage: 100%)
Gene name: B2m
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Ovalbumin Chain: P
Molecule details ›
Chain: P
Length: 8 amino acids
Theoretical weight: 964 Da
Source organism: Gallus gallus
Expression system: Not provided
UniProt:
  • Canonical: P01012 (Residues: 258-265; Coverage: 2%)
Gene name: SERPINB14

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 118Å b: 60.9Å c: 83.8Å
α: 90° β: 107.6° γ: 90°
R-values:
R R work R free
0.173 0.173 not available
Expression systems:
  • Drosophila melanogaster
  • Not provided

Quick links

Citations

18 review citations

The many important facets of T-cell repertoire diversity.
Nikolich-Zugich et al. (2004)
17 more

18 mentions without citation

Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity.
Selin et al. (2006)
17 more