› 1vry

Solution NMR

Second and Third Transmembrane Domains of the Alpha-1 Subunit of Human Glycine Receptor

Released:
DOI: 10.2210/pdb1vry/pdb
PDB entry 1vry coloured by chain, ensemble of 20 models, front view.
PDB entry 1vry coloured by chain, ensemble of 20 models, side view.
PDB entry 1vry coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and dynamics of the second and third transmembrane domains of human glycine receptor.
Ma D, Liu Z, Li L, Tang P, Xu Y
Biochemistry 44 8790-800 (2005)
PMID: 15952785

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149955 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycine receptor subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 76 amino acids
Theoretical weight: 8.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P23415 (Residues: 278-337; Coverage: 14%)
Gene name: GLRA1
Sequence domains: Neurotransmitter-gated ion-channel transmembrane region
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

5 review citations

The structural basis of function in Cys-loop receptors.
Thompson et al. (2010)
4 more

6 mentions without citation

Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors.
Burgos et al. (2016)
5 more