› 1w2s

X-ray solution scattering

Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ray scattering

Released:
DOI: 10.2210/pdb1w2s/pdb
PDB entry 1w2s coloured by chain, ensemble of 6 models, front view.
PDB entry 1w2s coloured by chain, ensemble of 6 models, side view.
PDB entry 1w2s coloured by chain, ensemble of 6 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study.
Gilbert HE, Eaton JT, Hannan JP, Holers VM, Perkins SJ
J Mol Biol 346 859-73 (2005)
PMID: 15713468

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133844 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Complement C3d fragment Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 34.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01024 (Residues: 995-1287, 1288-1299; Coverage: 19%)
Gene names: C3, CPAMD1
Sequence domains: A-macroglobulin TED domain
Complement receptor type 2 Chain: B
Molecule details ›
Chain: B
Length: 142 amino acids
Theoretical weight: 15.61 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P20023 (Residues: 20-153; Coverage: 13%)
Gene names: C3DR, CR2
Sequence domains: Sushi repeat (SCR repeat)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Expression systems:
  • Escherichia coli BL21
  • Komagataella pastoris

Quick links

Citations

7 review citations

X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution.
Putnam et al. (2007)
6 more

2 mentions without citation

Structural biology of complement receptors.
Santos-López et al. (2023)
1 more