› 1w3w

X-ray diffraction
1.99Å resolution

The 2.1 Angstroem resolution structure of annexin A8

Released:
DOI: 10.2210/pdb1w3w/pdb
PDB entry 1w3w coloured by chain, front view.
PDB entry 1w3w coloured by chain, side view.
PDB entry 1w3w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of annexin A8 is similar to that of annexin A3.
Réty S, Sopková-de Oliveira Santos J, Dreyfuss L, Blondeau K, Hofbauerová K, Raguénès-Nicol C, Kerboeuf D, Renouard M, Russo-Marie F, Lewit-Bentley A
J Mol Biol 345 1131-9 (2005)
PMID: 15644210

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146819 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Annexin A8 Chain: A
Molecule details ›
Chain: A
Length: 327 amino acids
Theoretical weight: 36.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P13928 (Residues: 1-327; Coverage: 100%)
Gene names: ANX8, ANXA8
Sequence domains: Annexin
Structure domains: Annexin

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE BEAMLINE DW32
Spacegroup: P21
Unit cell:
a: 50.761Å b: 65.581Å c: 59.229Å
α: 90° β: 100.7° γ: 90°
R-values:
R R work R free
0.177 0.175 0.218
Expression system: Escherichia coli BL21

Quick links

Citations

2 review citations

The role of annexins in tumour development and progression.
Mussunoor et al. (2008)
1 more

3 mentions without citation

Zooming into the Dark Side of Human Annexin-S100 Complexes: Dynamic Alliance of Flexible Partners.
Weisz et al. (2020)
2 more