› 1w8a

X-ray diffraction
2.8Å resolution

Third LRR domain of Drosophila Slit

Released:
DOI: 10.2210/pdb1w8a/pdb
PDB entry 1w8a coloured by chain, front view.
PDB entry 1w8a coloured by chain, side view.
PDB entry 1w8a coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of Slit.
Howitt JA, Clout NJ, Hohenester E
EMBO J 23 4406-12 (2004)
PMID: 15496984

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150143 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein slit N-product Chain: A
Molecule details ›
Chain: A
Length: 192 amino acids
Theoretical weight: 21.31 KDa
Source organism: Drosophila melanogaster
Expression system: Homo sapiens
UniProt:
  • Canonical: P24014 (Residues: 542-733; Coverage: 13%)
Gene names: CG43758, sli
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: C2
Unit cell:
a: 121.213Å b: 31.852Å c: 49.526Å
α: 90° β: 100.72° γ: 90°
R-values:
R R work R free
0.199 0.199 0.269
Expression system: Homo sapiens

Quick links

Citations

20 review citations

Regulation of commissural axon pathfinding by slit and its Robo receptors.
Dickson et al. (2006)
19 more

3 mentions without citation

Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors.
Matsushima et al. (2007)
2 more